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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Engles, J. Articles by Wahl, R. PubMed Articles by Engles, J. Articles by Wahl, R.

Comparative biodistribution of 18F-fluoro-2-deoxy-D-glucose (FDG) and eight radiolabeled amino acids in a rodent model of breast cancer

¹ Radiology, Johns Hopkins University, Baltimore, Maryland

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Objectives: Malignant transformation increases glycolysis but also often increases amino acid metabolism; therefore we evaluated the biodistribution of eight amino acids and FDG in a rodent model of breast cancer to determine their potential as imaging agents.

Methods: Tritiated L-methionine, valine, threonine, isoleucine, arginine, tyrosine, serine and lysine were co-injected intravenously with 18F-FDG into groups of female Lewis rats bearing rat mammary tumors. After sixty minutes, rats were sacrificed, tissues harvested, amino acid uptake measured and compared to 18F-FDG.

Results: FDG had significantly greater tumor uptakes values than amino acid tracers with the exception of methionine, arginine, and threonine. In areas of high physiological FDG uptake such as the brain and heart, several amino acids provided significantly superior tumor-tissue ratios than did FDG: lysine, threonine, tyrosine, valine, methionine, and arginine.

Conclusions: These experiments support several radiolabeled amino acids as promising tracers in areas of problematic FDG uptake.

Tumor to Tissue Ratios for FDG and Eight Radiolabeled Amino Acids in Female Lewis Rats Bearing RMT

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Engles, J. Articles by Wahl, R. PubMed Articles by Engles, J. Articles by Wahl, R.