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Development of methodology for the preparation of ⁹⁰Sr-⁹⁰Y generators at IPEN/CNEN-SP

¹ Radiopharmacy Center - CR, Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP, São Paulo, São Paulo, Brazil

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Objectives: ⁹⁰Y has a relatively short half-life (T_1/2=64h) decays to a stable daughter (⁹⁰Zr), emits β-radiation (Max. 2.28MeV) and has no -ray, what makes this nuclide very attractive for therapeutic applications. ⁹⁰Y is produced through a generator system, from the decay of ⁹⁰Sr (T_1/2=29y). In this work, the ⁹⁰Sr-⁹⁰Y generator was developed using a cation exchange resin method. ⁹⁰Sr is strongly adsorbed in the resin and ⁹⁰Y is eluted in 0.003M EDTA. The generator efficiency and radionuclide control results will be shown using also ⁸⁵Sr (-ray emitter).

Methods: The generator was developed, using AG 50WX8 exchange resin converted to the Na⁺ form and then conditioned with 0.003M EDTA solution (pH=4.8). The loading solution had 20µl of ⁹⁰Sr (55.5MBq) and 300µL of ⁸⁵Sr (28.7MBq) and the elution was perfomed with 0,003M EDTA. Activities of ⁹⁰Y and ⁹⁰Sr were determined by Liquid Scintillation Counting and ⁸⁵Sr by -ray spectroscopy using a HPGe detector. A paper chromatographic method was performed for the quality control, using Whatman3 paper and 0.9% NaCl as the solvent. In this case, the R_f of ⁹⁰Y is zero and the R_f of ⁹⁰Sr is about 1.

Results: Weekly elutions were performed for this generator. Between the 1^st and 4^th elution the ⁹⁰Y activity remained nearly constant. From the 5^th elution on, an increase in the ⁹⁰Y activity was noticed. The efficiency yield was 95% in the last elution. The breakthrough of ⁹⁰Sr was less than 0.04%. The quality control showed that ⁹⁰Y had no ⁸⁵Sr impurities, inside the detection limits of the detector.

Conclusions: The results presented here are very promising, showing that the methodology is able to separate the two nuclides, with low quantities of ⁹⁰Sr impurity and satisfactory elution yields.

Research Support: The research was supported by IAEA and CNPq granted a fellowship.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Barrio, G. Articles by Osso Jr., J. PubMed Articles by Barrio, G. Articles by Osso Jr., J., Jr.