SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):305P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Bozkurt, M.
Right arrow Articles by Metin, F.
PubMed
Right arrow Articles by Bozkurt, M.
Right arrow Articles by Metin, F.

Radiopharmaceutical Chemistry: Radiopharmacy

Radiopharmacy Posters

Inter and intraoperator reliability in quality control of Tc99m-MAG3 instant kit reconstitution

Murat Bozkurt1, Pinar Kiratli1, Deniz Konyali1 and Fatma Metin1

1 Nuclear Medicine Department, Hacettepe University Hospital, Ankara, Turkey

1300

Objectives: This prospective study was aimed to assess the inter and intraoperator variability during routine QC for MAG.

Methods: A total of 160 QC analysis with instant thin layer chromatography (ITLC) for 20 separate instant MAG kit reconstitutions were performed by 2 radiochemists (RC1&RC2).The percentage of free and hydrolysed Tc99m as well as binding efficiency were calculated according to standard ITLC.Each QC was done using silica gel (SG),silica acrylic (SA),Whatman 1 (WT1) and Whatman 3 (WT3) ITLC strips separately at 1 hour following labeling MAG instant kit with Tc99m-pertechnetate.Visual confirmation for QC with scintigraphy was also done.To assess radiochemical stability,the same analysis was performed 4 hours after kit reconstitution.At both time points,each RC repeated all the procedure twice for each ITLC paper type to analyse intraoperator reliability.Inter and intraoperator reliability ratios were acquired with Crombach’s Test.

Results: Interoperator and intraoperator correlation ratios per each ITLC strip were given in Table 1.Each showed adequate kit reconstitution with acceptable free and hydrolysed Tc99m percentages.The highest interobserver concordance was observed with SA.

Conclusions: The highest interoperator reliability in QC of MAG was achieved in the analysis done with SA paper, which is the recommended strip type by manufacturer.There was a high intraoperator reliability in QC for all ITLC strip types.


Figure 1
Inter and intraobserver concordance ratios of different ITLC strips





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Bozkurt, M.
Right arrow Articles by Metin, F.
PubMed
Right arrow Articles by Bozkurt, M.
Right arrow Articles by Metin, F.