SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):303P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Carter, E.
Right arrow Articles by Fischman, A.
PubMed
Right arrow Articles by Carter, E.
Right arrow Articles by Fischman, A.

Radiopharmaceutical Chemistry: New Chemistry-Other

New Chemistry-Other Posters

Biodistribution of CardioPET as a PET tracer for estimating and differentiating fat deposit function in mice

Edward Carter1, Timothy Shoup1, Daniel Winter1, Crystal Tolman1, David Elmaleh1 and Alan Fischman1

1 Radiology, MGH, Boston, Massachusetts

1292

Objectives: To evaluate the uptake behavior of CardioPET in brown and white fat in rats and in fed and fasted mice. In contrast to other species, adult mice keep brown fat adipose as a reserve energy supply. CardioPET (trans-9-[18F]fluoro-3,4-methyleneheptadecanoic acid), a modified fatty acid closely resembling naturally-occurring free fatty acids, undergoes metabolic trapping in heart tissue.

Methods: Normal fed and 24 hours fasted mice were injected with 100uCi of CardioPET. The mice were sacrificed at 30 minutes post injection and tissue distribution in %dose/gram was determined.

Results: Heart uptake was fast and pronounced. Other high uptake tissues were liver, kidney, bone and brown fat. Brown to white fat ratios varied from 3.2 in the fed mice to 4.5 in the fasted mice.

Conclusions: CardioPET injected into fed and 24 hour fasted mice showed lower fatty acid uptake in the fed mice. Brown fat was significantly higher than white fat in both nutritional conditions. CardioPET is a sensitive molecular imaging agent to study the behavior of white and brown adipose tissue lipids as a preferred substrate for thermogenesis during arousal from hibernation of animals by imaging.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Carter, E.
Right arrow Articles by Fischman, A.
PubMed
Right arrow Articles by Carter, E.
Right arrow Articles by Fischman, A.