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J Nucl Med. 2008; 49 (Supplement 1):29P
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Cardiovascular: Basic Science

New Approaches Using SPECT, PET and Hybrid Imaging

Evaluation of a new myocardial PET tracer 18F-BMS-747158-02 (18F-BMS): Comparison to 13N ammonia and validation with microspheres

Stephan Nekolla1, Sibylle Reder1, Takahiro Higuchi1, Saraste Antti1, M. Yu2, S. Robinson2, David Casebier2 and Markus Schwaiger1

1 Nuklearmedizinische Klinik, TU Muenchen, Muenchen, Germany; 2 Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts

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Objectives: PET tracers of myocardial blood flow (MBF) are commonly labeled with short lived isotopes which limits the clinical use. Thus, we evaluated 18F-BMS for resting and adenosine induced MBF in comparison to 13N ammonia (NH3) and microspheres.

Methods: 14 young pigs underwent dynamic PET after injection of either 700MBq of NH3 or 150/300MBq of 18F-BMS at rest and stress. In 8 pigs, the LAD was transiently ligated for 2.5 min during stress and 100MBq of 18F BMS was injected to simulate ischemia. Ratios of uptake in the left ventricle (LV) to surrounding tissues were determined and MBF was quantified using kinetic modeling. MBF measured with co-injected radioactive microspheres was used as reference.

Results: Both 18F BMS and NH3 showed high and homogeneous uptake throughout the LV in normal pigs at rest and stress. Clearly delineated defects were seen when 18F BMS was injected during LAD occlusion. Compared to NH3, 18F BMS showed two folds higher uptake ratios of myocardium to blood, liver and lungs. Quantitative analysis showed a good linear correlation (r2=0.78, slope=0.85) between MBF obtained by microspheres and 18F BMS in normal myocardium. Injection of 18F BMS during LAD occlusion showed a slightly reduced correlation (slope=0.72) for the ischemic areas. Extents of microsphere derived defects correlated very well with those calculated from 18F BMS uptake and MBF values.

Conclusions: 18F BMS-747158-02 is a promising new flow tracer with very high and specific myocardial uptake. MBF analysis of 18F BMS correlated closely with microspheres at rest and during stress. Furthermore, the new tracer appeared useful for detection of regional myocardial ischemia in our experimental model.





This Article
Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Nekolla, S.
Right arrow Articles by Schwaiger, M.
PubMed
Right arrow Articles by Nekolla, S.
Right arrow Articles by Schwaiger, M.