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J Nucl Med. 2008; 49 (Supplement 1):296P
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Radiopharmaceutical Chemistry: New Chemistry-Other

New Chemistry-Other Posters

A novel electrochemical approach for post elution concentration of 188Re

Rubel Chakravarty1, Ashutosh Dash1, Maroor R. Pillai2 and Meera Venkatesh1

1 Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India; 2 International Atomic Energy Agency, Vienna, Austria

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Objectives: 188Re from old 188W/188Re generators or generators with low specific activity 188W, yield dilute solutions of 188Re which need to be concentrated before radiolabeling. A simple electrochemical method was developed to address this issue.

Methods: 188Re from a dilute solution was deposited on platinum cathode in an electrochemical cell by applying optimal voltage and then recovered in 0.5 mL of 0.5 M HCl solution. Radiochemical and radionuclidic purity of the product were determined using standard techniques. The reproducibility of the result was confirmed by repeated experimentation. Concentrated 188Re thus obtained was used for labeling standard ligands such as HEDP and DMSA to ascertain the usability.

Results: Quantitative deposition of 188Re on the platinum electrode was achieved at a potential of 7V over a period of one hour in oxalic acid electrobath. 188Re deposition was best at pH 1-2. The overall yield of 188Re deposition was >85%. The recovered 188Re had high radiochemical (>97%) and radionuclidic purity (>99.99%). The efficiency of deposition and the quality of 188Re was found to be consistent on repeated experimentation. It was observed that 40ml of solution containing 296MBq (8mCi) of 188Re could be concentrated to 0.5ml. The compatibility of the product in the preparation of 188Re labeled formulations such as 188Re-HEDP and 188Re-DMSA was found to be satisfactory in terms of high labeling yields(>90%) and high radiochemical purity (>95%).

Conclusions: A simple electrochemical procedure was developed for the concentration of 188Re obtained from a generator. This method is adaptable for post elution concentration of 188Re obtained from a generator and the concentration factor could be very high as it is not dependent on the initial volume.





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Right arrow Articles by Chakravarty, R.
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