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J Nucl Med. 2008; 49 (Supplement 1):284P
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Radiopharmaceutical Chemistry: Dosimetry/Radiobiology

Dosimetry/Radiobiology Posters

Human biodistribution and dosimetry of the nucleoside analogue [18F]FAC in humans

Matthias Benz1, Caius Radu1, Martin Allen-Auerbach1, Nagichettiar Satyamurthy1, Micheal Phelps1, Johannes Czernin1 and Magnus Dahlbom1

1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California

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Objectives: The recently identified deoxycytidine analog [18F]-FAC (1-(2’-deoxy-2’-[18F] fluoroarabinofuranosyl) cytosine) has been reported to be a useful imaging probe for the detection of immune activation and evaluation of immunosuppressive therapy by microPET. The aim of the present study was to evaluate the human biodistribution and dosimetry of [18F]-FAC.

Methods: Biodistribution data were obtained from attenuation corrected whole-body PET scans of 3 healthy male subjects after a bolus injection of [18F]FAC (8.6±2.3 mCi). Emission scans were acquired 20, 48, and 76 min post injection. Radiation dosimetry estimates were calculated using the Olinda® software.

Results: The organs with the highest accumulation of [18F]FAC were the bladder, the kidneys, the spleen, the salivary glands, as well as the heart. The organs receiving the highest absorbed doses were the urinary bladder wall (2.06E-01 rem/mCi), the kidneys (1.06E-01 rem/mCi), the spleen (7.36E-02 rem/mCi), osteogenic cells (6.69E-02 rem/mCi), the heart wall (5.92E-02 rem/mCi), and the small intestine (5.80E-02 rem/mCi). The effective dose was 5.08E-02 rem/mCi, the effective dose equivalent was 5.98E-02.

Conclusions: The radiation dosimetry estimates show high agreement with the estimated dosimetry obtained from mice studies. The dose limiting organs are the urinary bladder wall and the kidneys.





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