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J Nucl Med. 2008; 49 (Supplement 1):268P
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General Clinical Specialties: Musculoskeletal

Musculoskeletal Posters

Evaluation of mandibular growth using 99mTc MDP SPECT: Comparison of 2D and 3D methods

Frederic Fahey1, Zachary Abramson2, Bonnie Padwa1, Leonard Kaban2 and S. Ted Treves1

1 Division of Nuclear Medicine, Children's Hospital Boston, Boston, Massachusetts; 2 Massachusetts General Hospital, Boston, Massachusetts

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Objectives: To compare 2D and 3D methods for the evaluation of mandibular growth using 99mTc MDP SPECT.

Methods: Thirty-two patients (10 male, 22 female, age 8-15, mean 14 years) referred for a 99mTc MDP scan not involving the face received an additional SPECT of the head. Subjects were injected with 99mTc MDP (7.4 MBq/kg) and imaged 3-4 hours later. An external reference (vial of known activity) was used. 2D and 3D ROIs were drawn for the two mandibular condyles and the clivus (used as an internal standard). For the 2D ROI, the slice through the hottest pixel was chosen and the ROI was centered on the feature. For the 3D ROI, the ROI data from 3 combined slices (the one containing the hottest pixel and above and below). Both the average and maximum pixel values within the ROI were analyzed with both the internal and external standards. These methods were applied to 8 patients referred for assessment of asymmetric mandibular growth and these early results are reported.

Results: The results using 2D and 3D methods were very highly correlated (r>0.99) yielding essentially identical information; most likely due to the small size of the feature relative to the resolution of SPECT. The maximum and average pixel vales were also very highly correlated (r>0.99), again due to the feature's small size. These results were consistent using either the internal or external standard. Of the 8 patients analyzed with our method, 5 were correctly identified as abnormal while 3 indicated quiescent stage of their disease.

Conclusions: Using the maximum pixel value and 2D ROIs is acceptable for the evaluation of mandibular growth using 99mTc MDP SPECT. The application of these methods with established normal ranges to a small group of patients demonstrated their utility.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Fahey, F.
Right arrow Articles by Treves, S. T.
PubMed
Right arrow Articles by Fahey, F.
Right arrow Articles by Treves, S. T.