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General Clinical Specialties: Infectious Disease/HematologyInfectious Disease/Hematology Posters |
1 Nuclear Medicine/Radiology; 2 Orthopedics; 3 Radiology/MSK, Mt. Sinai Medical School, New York, New York
1131
Objectives: The purpose of our study was to explore the utility of CT images in defining appropriate transformations to fuse MRI and SPECT In-111 WBC images. The fused images could be used to assess proper surgical approach in treatment of diabetic foot.
Methods: Five patients which had In-111 WBC SPECT/CT and MRI studies within a week, were investigated in an ongoing project. The In-111 activities used were in a range of 0.45-0.5 mCi. A GE Infinia SPECT/CT camera and Siemens MAGNETOM 1.5T MRI system were used in this study. First, the MRI and corresponding CT images were coregistrated using a transformation based on normalized mutual information (1). The transformation was saved and used for MRI and In-111 SPECT fusion. A phantom study was also performed.
Results: The cylinder phantom study with 0.1 mCi In-111 hot sphere showed that MRI/SPECT alignment using the approach described above produced registration with 0.7 +/- 0.4 mm accuracy in all three dimensions (3D). The five clinical cases were visually evaluated and showed 1-2 mm 3D fusion accuracy. The results indicate that accurate fusion of In-111 WBC SPECT/CT and MRI of feet is possible.
Conclusions: The CT in In-111 SPECT/CT studies can be used to accurately fuse and compare In-111 SPECT and MRI images of diabetic foot. This is expected to beneficially impact patient care and management.
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