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J Nucl Med. 2008; 49 (Supplement 1):264P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

The effects of age, density and menopausal state on FDG uptake in normal breast tissue and interactions among them

Ayse Mavi1, Tevfik Cermik2, Muammer Urhan2, Sandip Basu2, Halis Puskulcu3, Michael Yu2, Zhuang Hongming2 and Abass Alavi2

1 Nuclear Medicine, Yeditepe University Hospital, Istanbul, Turkey; 2 University of Pennsylvania, Philadelphia, Pennsylvania; 3 Izmir Institute of Technology, Izmir, Turkey

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Objectives: The aim was to investigate the effects of age, density and menopausal state on FDG uptake in the normal glandular breast tissue and interactions among them.

Methods: 149 patients with breast cancer (age:50.9±9.70 yr; range 32-77) who had contra-lateral normal breasts confirmed by MRI, mammography and PET were analyzed. The maximal and average standardized uptake value (SUVmax and SUVavg) of FDG (at 60.min)were measured.Subjects were divided into groups according to density and menopausal state. Descriptive statistics were used. Two-way factorial analysis of covariance was used to assess the effects of breast density, menopausal state and age to the values of SUVmax and SUVavg. Chi-Square test is used to test the relationship between menopausal state and density.

Results: Average age of patients with nondense breasts were significantly higher than that of patients with dense breasts (t=2.83, p<0.01). As the result of the relationships between age and menopausal state, breast density were found to be related with the menopausal state (c2=4.66, p<0.05). Dense breasts had an average of 1.243 SUVmax and 0.694 SUVavg while Nondense breasts had only 0.997 SUVmax and 0.592 SUVavg, respectively. The analysis of covariance showed that the density and linear effect of age were significant on both SUVmax and SUVavg.After removing the linear effect of age, menopausal state had no effect on SUVmax and SUVavg.

Conclusions: There is a significant decrease in FDG uptake as age increases and the breast density decreases. Age and density are independent factors and have significant effect on FDG uptake for both SUVmax and SUVavg. Menopausal state had no effect on FDG uptake.

Research Support: NIH funded





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Mavi, A.
Right arrow Articles by Alavi, A.
PubMed
Right arrow Articles by Mavi, A.
Right arrow Articles by Alavi, A.