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J Nucl Med. 2008; 49 (Supplement 1):261P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

18-FDG PET-CT imaging in transplanted patients follow-up: Preliminary results

Mara Catalano1, Sergio Piccolo1, Maria Luisa De Rimini1, Barbara Magliulo1, Francesco Barbato1, Marco Bifulco1 and Pietro Muto1

1 Diagnostic Imaging - Nuclear Medicine, AORN Monaldi, Naples, Italy

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Objectives: In recent years the increased incidence of post-tranplant tumors is certainly related to immune-suppressive therapy. Tumours more frequently found are lympho proliferative disorders (PTLDs) and Kaposi sarcoma (KS). Diagnosis is difficult and frequently reached when nodal involvement has already occurred. Aim of the study is to evaluate PET-CT accuracy in diagnosis, prognosis and therapeutic follow-up of these patients (pts).

Methods: 113 pts with cardiac graft and 12 pts with liver transplant were studied (age range 18-67 ys). They underwent both routine tests and WB 18FDG PET-CT.

Results: In 10/113 pts were diagnosed: 4 PTLDs indolent/smouldering, 2 aggressive immunoblastic lymphoma, 1 MM, 2KS and 1 NSCLC. 18FDG PET-CT was highly accurate in all cases, showing negative scans in PTLDs and positive ones in aggressive tumors, in NSCLC, in KS and MM. In the last two, post-treatment PET/CT was able to assess therapy efficacy.

Conclusions: In oncological lymphoproliferative and virus induced post-transplant diseases, PET/CT is accurate in diagnosis and follow-up and can be useful in monitoring and planning therapeutic strategies.





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