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J Nucl Med. 2008; 49 (Supplement 1):260P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Incremental value of integrated FDG PET/CT in evaluating indeterminate single pulmonary nodule for malignancy

Chi-Yung Chang1, Chen-Yi Cheng1, Chang-Hsian Liu2, C.Oliver Wong3 and Wen-Sheng Huang1

1 Department of Nuclear Medicine; 2 Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 3 Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan

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Objectives: To evaluate the incremental diagnostic value of integrated interpretation of PET/CT in evaluating solitary pulmonary nodules for malignancy.

Methods: A total of 117 patients (67 male and 50 female, mean age±SD: 61.7±13.6 years, range: 31-86 years) with indeterminate SPN and without previous history of malignancy were analyzed. The PET/CT was performed 1 hr after a 370 MBq 18F-FDG intravenous injection using an integrated PET/CT scanner (Siemens Biograph BGO duo). Patients fasted 6 hr prior the imaging. PET was interpreted alone or combined with CT and was graded with the five-point scale (J Nucl Med 2007;48: 214). Malignant diagnosis was based on histological findings, or a clinical and radiological follow-up of at least 15 months. Diagnostic performance of PET alone and PET/CT were performed using a discriminate analysis (SPSS Inc, Chicago, IL).

Results: PET alone classified correctly 86% and the integrated criteria increased the correct classification to 89% yet comparable sensitivity and specificity of 88% and 89% respectively. Eight PET equivocal cases by PET alone were resolved (>50%) cases when combined with CT interpretation.

Conclusions: While additional gain of integrated PET/CT from the non-contrast CT was limited, PET and CT are synergistic and significantly increment of diagnostic value in PET equivocal cases.





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