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J Nucl Med. 2008; 49 (Supplement 1):260P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Physiologic FDG uptake in the esophagus

Masahiko Takechi1, Seiei Yasuda1, Osamu Chino1, Hideo Shimada1, Hiroyasu Makuuchi1, Keiko Aoka2, Masahiro Ohta2 and Masayoshi Ito2

1 Tokai University School of Medicine, Kanagawa, Japan; 2 Yotsuya Medical Cube, Tokyo, Japan

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Objectives: The intestine is a well-known site of physiologic FDG uptake (PFU). In contrast, PFU in the esophagus is not well documented. We compared endoscopic findings and PET/CT findings to determine the frequency of PFU in the esophagus.

Methods: Study subjects were 500 asymptomatic individuals (299 men and 201 women; mean age, 53 years) who, between Nov 2005 and July 2006, underwent PET/CT study at our institution. Endoscopy was performed just prior to PET/CT. Thirty to 60 mins after endoscopy, 200 MBq FDG was injected, and 60 mins later, PET/CT was performed. PET/CT images were visually evaluated retrospectively, and FDG uptake in the esophagus equal to or higher than that in the liver was considered a positive PET finding.

Results: PET findings were negative for most subjects (486/500; 97.2%). High FDG uptake was observed at the terminal esophagus in 13 of the 500 subjects (2.6%), and longitudinal, high FDG uptake along the entire esophagus was observed in 1 of the 500 subjects (0.2%). Endoscopy revealed specific disorders in 197 of the 500 subjects (39.4%): reflux esophagitis (RE) (LA grade A) (78 cases), hiatal hernia (HH) (70 cases), Barrett’s esophagus (23 cases), ectopic gastric mucosa (12 cases), esophageal candida (8 cases), and others (12 cases). FDG uptake was not observed except in subjects with RE and/or HH. Significant correlation was observed between FDG uptake in the terminal esophagus and HH ({chi}2 test). In the subject with the longitudinal, high FDG uptake along the entire esophagus, no abnormality was detected endoscopically.

Conclusions: High FDG uptake in the esophagus was infrequent (2.8%) and was most often related to the presence of HH. The frequency of PFU in the esophagus is estimated to be equal to or less than 2.8%.





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Takechi, M.
Right arrow Articles by Ito, M.
PubMed
Right arrow Articles by Takechi, M.
Right arrow Articles by Ito, M.