| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
General Clinical Specialties: General Practice-OncologyGeneral Practice-Oncology Posters |
1 Clinical Radiology; ; 2 Health Sciences, Kyushu University, Fukuoka, Japan
1105
Objectives: The aim of this study was to evaluate the usefulness of FDG-PET/CT for residual lymph nodes (LNs) metastases in patients with differentiated thyroid carcinoma on radioiodine therapy.
Methods: The subjects were consisted of 26 patients with differentiated thyroid carcinoma who had no distant metastasis (M/F=8/18, age range =28 to 72 years). In all patients, total thyroidectomy and regional LNs dissection with or without extraregional LNs dissection were performed, and then radioiodine therapy was performed with 3.7 to 4.5GBq of I-131 NaI. FDG-PET/CT was performed after radioiodine therapy, and abnormal FDG uptake on LN were evaluated on visual analysis. The results were compared with serum thyroglobulin level and postablative I-131 whole body scan.
Results: 7 patients had abnormal FDG uptakes on LNs (total 8 lesions) that thought to be metastases. The serum thyroglobulin level were significant higher in patients with positive FDG uptakes (167.2±188.7ng/ml; mean±SD) than those of patients with negative FDG uptakes (40.9±54.4ng/ml) (p<0.05). These findings were more frequently seen in patients with high serum thyroglobulin level (38%; 6/16) than in patients with normal (less than 8ng/ml) (10%; 1/10), although this was not statistically significant. In 4 patients, no I-131 accumulation were observed in LNs with abnormal FDG uptake, and thought to be necessary for other treatment such as surgical resection.
Conclusions: FDG-PET/CT is thought to be useful to evaluate residual LNs metastases in patients with differentiated thyroid carcinoma on radioiodine therapy, and patients who had LNs with abnormal FDG uptakes are possible to be necessary for additional treatment.
| ||||||||||||||||||||||||||||
