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J Nucl Med. 2008; 49 (Supplement 1):258P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Brown adipose tissue in adults

Sanaz Lehman1, Aaron Cypess2, Gethin Williams1, Dean Rodman1, Ronald Kahn2 and Gerald Kolodny1

1 Nuclear Medicine, Beth Israel Medical Center, Boston, Massachusetts; 2 Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts

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Objectives: The development of positron emission tomography/computed tomography (PET-CT) scanning has led to recognition of brown adipose tissue (BAT). This is a source of false-positive scans in oncology patients. The objectives were to quantify prevalence of BAT uptake of FDG on PET/CT scans and assess for contributing factors.

Methods: PET-CT scans performed at the Beth Israel Deaconess Medical Center between October and March from 2003 to 2006 were reviewed. Patients with scans positive for BAT uptake of FDG (BAT positive) had their subsequent PET-CT scans reviewed. Further data were collected: baseline demographics, anthropomorphic data, smoking status, medical diagnosis, blood glucose level (BGL) and scan date. A control group matched by scan date was selected. Student’s t-test and Fisher’s exact test were used for analysis.

Results: 1288 different patients were scanned in the specified periods. 75 had BAT positive scans (5.8%). There were 656 scans for males with 23 BAT positive (3.5%) and 632 scans for females with 52 BAT positive scans (8.2%). The BAT positive population had a higher proportion of women (69%). Men with BAT positive scans were younger and more likely to be active smokers. There was no correlation between BAT positive scans and height, weight, BGL and medical diagnosis These 75 patients had a total of 157 scans, 35 done in warm-weather months. There was a significant association between FDG uptake and outdoor temperature, with BAT uptake of FDG almost exclusively detected between September and April.

Conclusions: A significant portion of the adults population scanned for oncologic indications showed BAT uptake of FDG. Cold weather, female gender, and in men younger age and active smoking were associated with increased presence of BAT uptake of FDG on PET-CT scans.





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Lehman, S.
Right arrow Articles by Kolodny, G.
PubMed
Right arrow Articles by Lehman, S.
Right arrow Articles by Kolodny, G.