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General Clinical Specialties: General Practice-OncologyGeneral Practice-Oncology Posters |
1 Nuclear Medicine; 2 Endocrinology, Chonnam National University Hospital, Gwangu-ju, South Korea
1101
Objectives: Purpose of this study is to evaluate clinical significance of focal thyroid lesions incidentally detected on PET/CT and to elucidate factors suggesting malignancy.
Methods: Three hundred and nineteen of 9087 patients (3.5%) showed focal thyroid uptake on PET/CT. One hundred and forty-nine patients underwent neck ultrasonography, fine needle aspiration cytology or operation. Thyroid lesions were studied by 5 variables: maxSUV, size, presence of other thyroid lesions, calcification on PET/CT, and underlying malignancy. Independent t-test and logistic regression analysis were performed.
Results: Pathology revealed 92 (61.7%) benign and 57 (38.3%) malignant findings. maxSUV of malignant thyroid lesions was higher than that of benign thyroid lesions (8.7±10.2 vs. 6.3±7.4). However, there was no statistically significant difference (p=0.071). Thyroid lesions with calcification on PET/CT had a significantly higher malignancy rate than that without calcification (24.6% vs. 12.0%, p=0.045). Thyroid lesions of patients with underlying malignancy had a significantly higher malignancy rate than that without underlying malignancy (71.9% vs. 54.3%, p=0.032). On multiple regression analysis, calcification on PET/CT and underlying malignancy was statistically significant in distinguishing benign and malignant thyroid lesions (p=0.017, 0.021; OR=2.885, 2.309, respectively).
Conclusions: Focal thyroid lesions incidentally detected on PET/CT has a high risk of malignancy. Especially, when focal thyroid lesion with underlying malignancy and calcification on PET/CT has a 2 times higher malignancy rate and diagnostic confirmation is mandatory.
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