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J Nucl Med. 2008; 49 (Supplement 1):257P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Pathologic significance of sentinel lymph node mapping failure in breast cancer

Lee Pei-Ing1, You Dong-Ling1, Yu Ben-Long2, Tsou Mei-Hua3 and Huang Yu-Yi1

1 Nuclear Medicine; 2 Surgery; 3 Pathology, Koo Foundation Sun-Yat Sen Cancer Center, Taipei, Taiwan

1098

Objectives: The aim of this study is to evaluate whether axillary sentinel lymph node (SLN) mapping failure is associated with higher incidence of nodal metastasis.

Methods: A retrospective review was performed in 1013 early breast cancer patients who received SLN study between July 2002 and November 2007. Twelve of these patients received 2 SLN studies each for bilateral breast cancers. All patients received subdermal injection of 0.3-0.7mCi of Tc-99m sulfur colloid around the tumor on the day of surgery. Anterior and lateral static images were obtained 30min, 1h, 2h and 3h after injection. SLN mapping failure was defined as non-visualization of axillary SLN on 3h delayed image. SLNs were localized intra-operatively with gamma-probe. Pathologic status of lymph nodes was analyzed by hematoxylin-eosin and immunohistochemical stains. The incidence of axillary lymph node metastasis was compared between successful and mapping failure groups.

Results: There were 1025 SLN studies performed in 1013 patients. Of these, 1009 (98.4%) studies had successful SLN mapping and 16 (1.6%) had SLN mapping failure. Axillary lymph node metastasis was identified in 259 (25.7%) studies with successful SLN mapping. Eight (50.0%) of 16 studies with SLN mapping failure showed nodal metastasis. The incidence of nodal metastatis was statistically higher in patients with SLN mapping failure (p<0.05).

Conclusions: Patients with SLN mapping failure have a higher incidence of axillary lymph node metastasis.





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Right arrow Articles by Pei-Ing, L.
Right arrow Articles by Yu-Yi, H.
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Right arrow Articles by Pei-Ing, L.
Right arrow Articles by Yu-Yi, H.