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J Nucl Med. 2008; 49 (Supplement 1):254P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

PET-CT for evaluation of treatment response in high-grade lymphoma

Ajay Yadav1, Rakesh Kumar1, Halanaik Dhanapathi1, Atul Sharma1, Chandra Bal1 and Arun Malhotra1

1 Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

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Objectives: Till now, most of the studies were done on this topic by using 18F-FDG-PET alone. Present study was planned to assess the role of 18F-FDG PET/CT in evaluation of treatment response in patients of HD and NHL.

Methods: We prospectively analyzed 52 patients (33 NHL and 19 Hodgkin's disease) of high-grade lymphoma. Pre-treatment and post-treatment PET/CT of all the patients were done by injecting 10 mCi 18F-FDG and scanned approximately 60min later. The PET/CT used in this studies was Biograph64/Siemens having LSO (Lutetium oxyorthosilicte, Lu2SiO5:Ce) detectors with attenuation coefficient 0.89 cm-1, photo fraction 30%, decay constant 40ns and energy resolution at 511 KeV (% FWHM) is 10 with spatial resolution of 6mm. The results of 18F-FDG PET/CT were compared with the results of CT and clinical outcome; the presence of relapse was determined on the basis of positive biopsy results or clinical follow-up data.

Results: Of the 52 post treatment PET/CT scans, 47 showed no pathologic FDG uptake, whereas 5 showed persistent FDG uptake. Among the 47 patients who had negative PET scans, only 1 patient (2.2%) relapsed, whereas all 5 patients (100%) who had persistent abnormal 18F-FDG uptakes on post therapy PET/CT scans relapsed. The sensitivity, specificity, positive and negative predictive values, and accuracy of post therapy 18F-FDG PET were 83.33%, 100%, 100%, 98%, and 98.07%, respectively.

Conclusions: 18F-FDG PET/CT has potential value in monitoring the response to treatment in patients with both NHL and HD. PET-CT provide functional and anatomic details in same settings. In addition, CT data is utilized for attenuation correction of PET images. Thus, PET/CT offers several advantages including shorter image acquisition time, improved lesion localization and identification and more accurate.





This Article
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Right arrow Articles by Malhotra, A.
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Right arrow Articles by Yadav, A.
Right arrow Articles by Malhotra, A.