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J Nucl Med. 2008; 49 (Supplement 1):253P
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General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Incidental thyroid lesions detected with PET/CT

Masao Ono1, Katsuyuki Kobayashi1, Hironari Kimura1, Tatsuya Katoh1, Toyoyuki Kojima1, Takashi Ushimi1, Kazuyoshi Akiyama1 and Seiei Yasuda1

1 Yotsuya Medical Cube, Tokyo, Japan

1082

Objectives: High FDG uptake is occasionally observed in the thyroid during PET/CT study. The aim of the study was to determine the frequency of high FDG uptake in the thyroid and the diseases that can be detected incidentally with PET/CT.

Methods: From Aug. 2005 to July 2007, 2514 asymptomatic individuals (1534 M, 980 F, 54.4±11.9 yo) underwent PET/CT study at our institution. PET/CT was performed 60 min after inj. of 200 MBq FDG. PET/CT images were visually evaluated, and thyroid FDG uptake was classified prospectively as 1) diffuse, 2) localized, or 3) negative, i.e., no increased uptake. Individuals with diffuse thyroid uptake were further evaluated by serum hormone and antibody studies with or without US. Individuals with localized thyroid FDG uptake were further evaluated by US with or without aspiration cytology. PET findings were compared to the final diagnoses obtained from these examinations.

Results: Diffuse thyroid FDG uptake was observed in 96 of 2514 (3.8%)


Figure 1

. Further studies revealed chronic thyroiditis in 93% of them, and no abnormality was identified in 7%. Localized thyroid FDG uptake was observed in 26 individuals (1%), and thyroid carcinoma was identified in 38% of them. Overall, the PET-positive rate was 4.8%, and the positive predictive value in detecting thyroid lesions was as high as 95% (58/ 61).

Conclusions: Because FDG accumulation in the thyroid correctly points to the presence of thyroid lesions, further studies should be conducted considering the patterns of thyroid FDG uptake.





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