J Nucl Med. 2008; 49 (Supplement 1):250P
General Clinical Specialties: General Practice-OncologyGeneral Practice-Oncology Posters |
The role of F18-fluoride PET/CT in bone metastasis: Comparison with F18-fluoride PET and Tc99m-MDP bone scintigraphy
Masashi Kawaguchi1,
Akiko Suzuki1,
Keisuke Yoshida1,
Kazuya Shizukuishi1,
Jin Lee1 and
Tomio Inoue1
1 Dept. of Radiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
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Objectives: The purpose of this study is to evaluate the role of F18-fluoride (NaF) PET/CT in the detection of bone metastasis compared with NaF PET and Tc99m-MDP bone scintigraphy.
Methods: Five cancer patients with suspected skeletal involvement who underwent NaF PET/CT and Tc99m-MDP bone scintigraphy (BS) were enrolled. NaF PET and NaF PET/CT were interpreted separately. The final diagnosis of lesions was based on correlation with other imaging modalities and/or clinical follow-up.
Results: A total of 95 lesions were identified. Seven lesions were excluded because of the absence of confirmed reference data. Finally, a total of 88 lesions were diagnosed as bone metastases (n=66) or benign lesions (n=22). The sensitivity and specificity of BS, NaF PET and PET/CT were 44%/95%, 86%/82% and 98%/100%, respectively. The sensitivity of NaF PET and PET/CT were superior to that of BS (86%, 98% vs. 44%, p<0.05). There were no significant difference between the specificity of BS and that of NaF PET/CT. Although there was no statistical difference, the specificity of NaF PET/CT was higher than that of NaF PET alone (100% vs. 82%).
Conclusions: Compared with NaF PET and BS, NaF PET/CT is a highly sensitive and specific modality, which may play an important role in the detection of bone metastasis.
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Comparison of bone scintigraphy, NaF PET and PET/CT results in assessment of bone metastasis.
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