SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):24P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Croteau, E.
Right arrow Articles by Bénard, F.
PubMed
Right arrow Articles by Croteau, E.
Right arrow Articles by Bénard, F.

Instrumentation & Data Analysis: Data Analysis & Management

Quantitative Methods

Validation of femoral artery input function measured by PET for tracer kinetic modeling of skeletal muscle

Etienne Croteau1, Sébastien Ménard2, Roger Lecomte1, André Carpentier2 and François Bénard1

1 Nuclear Medicine and Radiobiology; 2 Endocrinology, Université de Sherbrooke, Sherbrooke, Quebec, Canada

93

Objectives: PET imaging can be used to investigate the effects of diabetes and genetic susceptibility to diabetes on skeletal muscle metabolism and perfusion. The purpose of this study was to validate the use of the femoral artery (FA) as the input function (IF) in PET images for tracer kinetic modeling with 11C-acetate (AC) and 18F-fluoro-6-thia-heptadecanoic acid (FTHA).

Methods: The approach was validated with two phantom systems. First, various radioactive cylinders were used to determine recovery coefficient (RC) factors. Second, a tubing with constant flow was used to simulate first pass of a radiotracer and confirm the validity of an external noninvasive PET measurement of IF. RC was then applied to the data from 6 patients who received 2 consecutive injections of 5 mCi of AC and FTHA. Data were compared to measurements obtained with arterialized venous blood.

Results: Uncorrected PET time activity curve (TAC) from FA led to underestimated activity compared to blood samples and significantly affected femoral muscle perfusion extracted with AC and a three compartment model (0.96 ± 0.50 min-1 without correction vs 0.35 ± 0.27 min-1 with RC correction). The latter result is not statistically different from that obtained with blood samples (0.35 ± 0.34 min-1). Similarly, the fatty acid metabolic rate measured with FTHA extracted by the Patlak method using corrected FA TAC yielded 0.94 ± 0.41 min-1, which was close to the values of 1.13 ± 0.49 min-1 calculated from the arterialized venous plasma.

Conclusions: FA TAC data corrected for partial volume effect as measured noninvasively by PET imaging can be used as a substitute of arterial blood sampling to perform tracer kinetic modeling in skeletal femoral muscles.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Croteau, E.
Right arrow Articles by Bénard, F.
PubMed
Right arrow Articles by Croteau, E.
Right arrow Articles by Bénard, F.