J Nucl Med. 2008; 49 (Supplement 1):246P
General Clinical Specialties: General Practice-OncologyGeneral Practice-Oncology Posters |
FDG-PET is more accurate than CT/MRI for evaluating therapy response in patients with malignant lymphoma
Kayako Isohashi1,
Mitsuaki Tatsumi1,
Ichiro Higuchi1,
Atsuo Inoue1,
Kazuya Nakajyo1,
Eku Shimosegawa1 and
Jun Hatazawa1
1 Department of Nuclear Medicine, Osaka University Graduate School of Medicine, Suita, Japan
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Objectives: To evaluate an diagnostic accuracy of FDG-PET(PET)for staging/restaging, therapy response, and recurrence in patients with malignant lymphoma (ML) having long-term follow-up and to compare with that of CT/MRI.
Methods: This study consisted of 59 ML patients having whole-body PET exams three times or more from October 1998 to August 2006. Locations of the lesions with positive findings on PET and/or corresponding CT/MRI were classified into 10 supradiaphragmatic, 8 infradiaphragmatic, and 20 extranodal sites, and the findings were compared on a site basis according to the gold standard, which consisted of all clinical information available including follow-up results.
Results: A total of 156 PET exams having corresponding CT/MRI were evaluated, and 305 sites showed positive findings on PET and/or CT/MRI. Concordant positive findings were obtained in 76% for staging/restaging, 34% for evaluation of treatment response and 50% for screening of recurrence. The accuracy of PET vs. CT/MRI was 92% vs.84% (p=0.06) for staging/restaging, 84% vs. 50% (p< 0.05) for evaluation of treatment response, and 83% vs. 72% (p=0.21) for screening of recurrence, respectively. In pathologic sites with discrepant findings between PET and CT/MRI (n=122), the frequency of accurate diagnosis with PET(76%)was higher than CT/MRI(24%)for evaluation of treatment response.
Conclusions: FDG-PET is more accurate than CT/MRI for evaluating therapy response in patients with malignant lymphoma.
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Concordant positive findings and the accuracy of PET and CT/MRI exams
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