SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):246P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Grassetto, G.
Right arrow Articles by Rubello, D.
PubMed
Right arrow Articles by Grassetto, G.
Right arrow Articles by Rubello, D.

General Clinical Specialties: General Practice-Oncology

General Practice-Oncology Posters

Adrenal incidentalomas: Role of 18F-FDG PET in the diagnostic work-up

Gaia Grassetto1, Lucia Rampin1, Elena Banti1 and Domenico Rubello1

1 Nuclear Medicine Unit, S. Maria della Misericordia Hospital, Rovigo, Italy

1053

Objectives: To establish the role of FDG-PET in diagnostis work-up in pts with adrenal incidentaloma at conventional imaging (CT/US/MR).

Methods: 74 pts (54 with neoplastic history) with finding of an adrenal incidentaloma at conventional CT/US/MR were studied by FDG-PET. A bio-chemical and hormonal profile (cortisol, ACTH, catecholamine, etc) was routinely obtained. PET was performed by a hybrid PET/CT system (GE, Discovery LS) in fasting condition. FDG 5.4 MBq/kg b.w. was injected 1 hr before examination.

Results: FDG-PET showed significant FDG uptake in the adrenal incidentaloma in 32 pts, 28 with a neoplastic history, and 4 without. Incidentaloma size ranged 1 to 4 cm, median 2.2. SUVmax ranged from 4.3 to 21.4, median 8.5. At surgery, a metastasis was diagnosed in all the 28 FDG-positive pts with a neoplastic history. In the other 16 pts of this group hormonal tests were normal, and in 6 cases radiocolesterol scan revealed a benign adenoma; they entered a CT scan program. Among the 4 pts without a neoplastic history, 3 were FDG-negative; radiocolesterol and MIBG scans resulted negative, and were considered to be affected by a benign adrenal adenoma: they entered a CT follow-up program The other one patient of this group was FDG-positive and MIBG-positive: a pheochromocytoma was diagnosed.

Conclusions: Our data show that a FDG-positive adrenal incidentaloma in a pt with an oncologic history the probability of being affected by an adrenal metastasis is very high. Instead in FDG-negative pts without neoplastic history diagnosis of benignity is mostlikely: the only exception can be due to the presence of a pheochromocytoma. Thus, in our experience, a FDG-PET is strongly useful as a first-choice examination to be performed in pts with an adrenal incidentaloma at conventional imaging and a neoplastic history.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Grassetto, G.
Right arrow Articles by Rubello, D.
PubMed
Right arrow Articles by Grassetto, G.
Right arrow Articles by Rubello, D.