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General Clinical Specialties: EndocrinologyEndocrinology Posters |
1 Medecine Nucleaire, Hopital Antoine Beclere, Clamart, France
1033
Objectives: The aim of the study was to evaluate the additional value of I-131 SPECT/CT images in comparison with I-131 whole-body planar images in the follow-up of patients with differentiated thyroid carcinoma (DTC).
Methods: Thirty three consecutive patients (25 women, 8 men; age range 27-84 years) with DTC, 6 follicular and 27 papillary types, were prospectively included for I-131 scanning after therapeutic radioiodine doses in 15 cases and after diagnostic doses during TSH-stimulation by recombinant human TSH in 20 cases, using a SPECT/CT system which combines a dual-detector gamma camera with a 2 slices spiral CT. Whole-body planar images were performed in all patients followed by SPECT/ CT images in 20 patients.
Results: Among the 33 patients, 15 underwent SPECT/CT for evaluation of findings in the thyroid bed (group 1) and 5 for evaluation of foci distant from the neck (group 2). In group 1, SPECT/CT images had an additional diagnoctic value in 5 patients (33 %) while in all patients of the second group, SPECT/ CT allowed to a precise characterization and localization of pathological (n=3) or physiological uptake (n=2). Overall, SPECT/CT had an additional diagnostic value in 10 of 20 patients (50 %) and according to clinical and imaging follow-up, non-malignant tissue was confirmed in 15 patients and malignant tissue (lymph nodes,lungs and bone) in 5 patients.
Conclusions: We conclude, that anatomical information provided by CT enables precise localization of abnormalities observed in planar images and reduces false positive results. Therefore, image fusion provides a good accuracy for tumor detection in patients with differentiated thyroid carcinoma.
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