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J Nucl Med. 2008; 49 (Supplement 1):240P
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General Clinical Specialties: Endocrinology

Endocrinology Posters

Efficacy of low-dose I-131 therapy for the postoperative ablation of low-risk differentiated thyroid cancer patients

Meltem Caglar1, Murat Bozkurt1, Ceren Kapulu1, Omer Ugur1 and Miyase Bayraktar2

1 Nuclear Medicine Department; 2 Endocrinology, Hacettepe University Hospital, Ankara, Turkey

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Objectives: Contraversy still exists on the amount of I-131 dose and ablation success criteria especially for the low-risk differentiated thyroid cancer patients.The aim of this prospective study was to assess the efficacy of low-dose I-131 therapy for the postoperative ablation of low-risk thyroid cancer patients.

Methods: Between December 2006 and December 2007 a total of 41 patients (4m,37f, mean age:46.9±23.1) were enrolled as study group. All patients had diagnosis of low-risk thyroid cancer.After total thyroidectomy all patients were given 21 mCi I-131 when serum TSH≥30 ng/ml, if the remnant received 300 Gy which is the minimum dose required for successful ablation.The ablation efficacy of 21 mCi I-131 study group was compared to that of control group which consisted of 20 patients with diagnosis of low-risk thyroid cancer who received standard 100 mCi ablation dose

Results: In our study group 20 out of 41 patients were re-evaluated at 6 months after therapy. Whole-body I-131 (WB) scan, thyroid ultrasonography (USG), Tg, anti Tg Ab measurements were performed.Successful ablation was defined as minimal or no neck uptake on I-131 WB scan, no remnant tissue on thyroid USG with Tg levels ≤2 ng/ml and Anti-Tg≤20 ng/ml when TSH≥30 mIU/ml. Based on the selected criteria the ablation success rate was 65% and 45% for the low and high dose groups respectively.

Conclusions: The low-dose I-131 therapy on an outpatient setting is an efficient therapeutic option for the low-risk thyroid cancer patients.





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