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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kang, S. Articles by Lee, J. PubMed Articles by Kang, S. Articles by Lee, J.

Optimal timing of diagnostic I-123 whole body scan in the patient with differentiated thyroid cancer: Comparison between 6 and 24 hour images of same subjects

¹ Kyungpook National University Hospital, Daegu, South Korea

1013

Objectives: Iodine-123(I-123) diagnostic scan plays a role of in the detection of metastasis in patients with differentiated thyroid cancer (DTC). The purpose of this study is to compare the image quality of 6 and 24 hour image of I-123 diagnostic scan for recurrence or metastasis in the patient with DTC.

Methods: 534 patients(female=475, mean age: 47.5±12.8 years) after thyroidectomy and high dose I-131 therapy underwent diagnostic whole body scans obtained 6 hour & 24 hour after oral ingestion of 5mCi of I-123. Serum thyroglobulin levels were available for all patients with thyroid hormone off state. According to the results of I-123 scan, thyroglobulin, USG and PET/CT, 40 patients underwent I-131 therapy.

Results: Four hundred eighty patients (89.8%) showed concordant findings but 54 patients (10.1%) showed discordant findings in 6 and 24 hour images. Of 54 discordant patients, 30 patients showed abnormal uptake (neck and lung) in 6 hour image but negative findings in 24 hour image, which revealed no evidence of recurrence or metastasis in thyroglobulin, PET/CT and ultrasonography. Twenty four patients showed negative findings in 6 hour image but bed and lymph node uptake in 24 hours image, which turned out true lesions in post-therapy I-131 scan, ultrasonography, PET/CT and histological confirmation. There were no false positive findings in 24 hours image.

Conclusions: 24 hour images of I-123 scan show superior image quality and accurate diagnostic results compared with 6 hour image in the patient with DTC.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kang, S. Articles by Lee, J. PubMed Articles by Kang, S. Articles by Lee, J.