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J Nucl Med. 2008; 49 (Supplement 1):231P
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Neurosciences: Neurology

Neurology Posters

Validation of a 18F-FDG SPM template for brain pediatric application

Maria-Joao Santiago-Ribeiro1, Thierry Delzescaux1, Claire Leroy1, Arnaud Cachia1, Catherine Chiron1, Andre Syrota1 and Regine Trebossen1

1 CEA, Orsay, France

993

Objectives: Statistical parametric mapping (SPM) is a powerful technique for the comparison of functional images among groups. Reliable comparisons require accurate normalization and image registration to a standard template. Pediatric brain application most often uses an adult’s template. Such procedure introduces artifacts in SPM analysis. The aim of this study is to create and to validate an 18F-FDG pediatric brain template.

Methods: 44 children 18F-FDG images were included: 28 cryptogenic epileptic and 16 degenerative-like neuro-Langerhans histiocytosis (DLN-LH) patients. PET images were collected for 20 min 30 min after the 18F-FDG injection with an ECAT EXACT HR+ (Siemens Medical Solutions). T1 images were obtained using a 1.5 Tesla MRI (Signa, General Electric). Two 18F-FDG templates were constructed: one based on T1 SPM5 template (adult template) and one on a MRI pediatric homemade template. For each subject, 18F-FDG image was registered and normalized to both adult and pediatric templates using SPM5. The two pediatric groups were then compared with t statistic test further transformed into statistic (SPM[Z]) maps.

Results: Statistic maps show artifacts covering the whole cerebellum that are more pronounced with the adult template than with the pediatric template. SPM analysis between the two groups revealed significant hypometabolism in several regions of DLN-LH patients (caudate nuclei and cerebellum, both affected by artifacts).

Conclusions: Normal brain development during childhood is a complex and dynamic process which results in a high degree of variability of the brain shape and size. Our results indicate that the spatial normalization of pediatric brains to an adult template causes a high degree of artifacts in SPM maps. Therefore, the design of pediatric templates needs to be undertaken in order to apply SPM in this age population.





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Right arrow Articles by Santiago-Ribeiro, M.-J.
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