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J Nucl Med. 2008; 49 (Supplement 1):230P
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Neurosciences: Neurology

Neurology Posters

Striatal dopamine release induced by repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex: Effect of aging

Ji Hee Hwang1, Sang Soo Cho1, Sung Ae Bang1, Eun Jin Yoon1, Ji Sun Kim1, Byung Chul Lee1, Yu Kyeong Kim1 and Sang Eun Kim1

1 Seoul National University College of Medicine, Seoul, South Korea

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Objectives: We investigated how frontal activation by repetitive transcranial magnetic stimulation (rTMS)influences striatal dopamine(DA) release in the elderly with SPECT measurements of striatal binding of [123I]iodobenzamide (IBZM), a DA D2 receptor radioligand that is sensitive to endogenous DA.

Methods: Five healthy elderly male subjects (age, 64 ± 3 y) were studied with brain [123I]IBZM SPECT under three conditions (resting, sham stimulation, and active rTMS over left dorsolateral prefrontal cortex (DLPFC)), while receiving a bolus plus constant infusion of [123I]IBZM. rTMS session consisted of three blocks. In each block, 15 trains of 2 sec duration were delivered with 10 Hz stimulation frequency and 100% motor threshold. Striatal V3", calculated as (striatal – occipital)/occipital radioactivity, was measured under equilibrium condition at baseline and after sham and active rTMS.

Results: Sham stimulation did not affect striatal V3". rTMS over left DLPFC induced no significant change in V3" in the right striatum compared with baseline condition (0.91 ± 0.25 vs. 0.96 ± 0.25, P = NS). Interestingly, left striatal V3" showed a significant increase after rTMS over left DLPFC compared with sham condition (1.09 ± 0.33 vs. 0.93 ± 0.27, P < 0.05; 17.0 ± 11.1% increase). These results are discrepant from previous ones from young subjects, who showed frontal rTMS-induced reduction of striatal V3", indicating rTMS-induced striatal DA release.

Conclusions: We found no significant striatal DA release induced by rTMS over DLPFC in healthy elderly subjects using in vivo binding competition techniques. These results may support an altered corticostriatal circuit in normal aging.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Hwang, J. H.
Right arrow Articles by Kim, S. E.
PubMed
Right arrow Articles by Hwang, J. H.
Right arrow Articles by Kim, S. E.