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Oncology-Clinical Diagnosis: Solid TumorsGenitourinary Cancers |
1 Nuclear Medicine; 2 Radiation Oncology, University of Geneva, Geneva, GE, Switzerland
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Objectives: To investigate dynamic FCH uptake evolution of malignant lesions of the prostate bed (MPB) compared to AILN.
Methods: Patients with confirmed prostate cancer (13 local relapses, 4 initial presentations) underwent dynamic prostate bed scan followed by whole body FCH PET/CT. Data from MPB were analyzed in comparison to AILN. Maximal standardized uptake values (SUV) of MPB and AILN were calculated for frames of 0-3, 3.1-6, 6.1-9 and 11-13 min. for all lesions. Delayed prostate bed images were obtained 38-43 min. p.i. in 13 cases. To bypass potential partial volume effects in small lesions, all SUV’s were expressed as proportion of the respective value at 0-3 min. (normalization). Statistical analysis comprised student’s T-test for raw SUV’s and robust linear regression for dynamic evolution of normalized data.
Results: 24 FCH positive lesions were analyzed: 6 AILN and 18 MPB. Histologically confirmed MPB showed progressive increase of SUV until 13 minutes post injection and a trend for stabilization until late scan, whereas AILN consistently showed decreasing SUV.
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Linear regression analysis showed a highly significant difference (p<0.001) between MPB and AILN.
Conclusions: Dynamic FCH PET/CT showed a significantly different evolution between MPB and AILN. A similar mechanism might be the the reason for FCH uptake observed in activated non-specific mediastinal lymph nodes.
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