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J Nucl Med. 2008; 49 (Supplement 1):229P
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Neurosciences: Neurology

Neurology Posters

Effect of low frequency rTMS stimulation over lateral cerebellum: FDG PET activation study

Hyun Soo Park1, Eun Jin Yoon1, Sung Ae Bang1, Sang Soo Cho1 and Sang Eun Kim1

1 Seoul National University College of Medicine, Seoul, South Korea

988

Objectives: Several lines of evidence suggested the involvement of cerebellum in cognitive function as well as motor function. To understand the role of cerebellum within the neural network, we investigated the changes of neuronal activity elicited by the cerebellar repetitive transcranial magnetic stimulation (rTMS).

Methods: 11 right-handed normal volunteers (age: 23.4±2.5 y; 6 males) were studied with FDG PET under two conditions; sham and 1Hz rTMS over left lateral cerebellum. With 10 min inter-block interval, three blocks of rTMS were started with the intravenous injection of [18F]FDG. In each block, 5min rTMS were delivered with an intensity of 90% of the resting motor threshold (RMT). Sham rTMS was delivered with same protocol but the coil was positioned perpendicular to the target area with 50% RMT. PET scans were acquired immediately after the rTMS stimulation. Sham and 1Hz rTMS images compared using paired t-test with SPM2.

Results: Inhibited neuronal activity compare to the sham condition were revealed in the stimulated left lateral cerebellum and orbitofrontal gyrus and right motor related areas (S1, SMA and posterior parietal cortex). While enhanced neuronal activity compare to the sham condition were revealed in the bilateral inferior frontal gyri including Broca’s area and superior temporal gyrus including primary auditory cortex. Bilateral middle temporal, left precentral and right middle occipital gyri were also showed enhanced neuronal activity.

Conclusions: This result showed that rTMS over left lateral cerebellum modulate direct vicinity of the targeted region and a large network of remote interconnected contralateral motor and ipsilateral language related brain regions. Present result provide evidence that cerebellum may contribute to language related cognitive function as well as motor control.





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Right arrow Articles by Kim, S. E.