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Neurosciences: NeurologyNeurology Posters |
1 Nuclear Medicine; 2 Neurology, University at Buffalo, Buffalo, New York
985
Objectives: Sleep apnea is a multiorgan disease characterized by numerous apneic episodes, or arterial oxygen desaturation and various cardiovascular manifestations. The exact etiology of obstructive sleep apnea (OSA) is unknown. Subjects suffering from OSA often exhibit neurologic manifestations, particularly temporary memory loss. The purpose of this study was to: 1) assess cerebral metabolism through imaging with F-18 FDG PET in patients with OSA and 2) determine the short and long term effects of treatment with CPAP (continuous positive air pressure) on FDG cerebral distribution.
Methods: Six subjects with newly diagnosed, CPAP naïve, severe OSA (RDI > 30 respiratory distress index) received a baseline FDG (3.5 mg) PET scan which was repeated one week and 6-8 weeks following CPAP treatment. All patients were allowed to sleep during the PET study.
Results: Five subjects completed 3 scans each; one patient dropped out. The PET scans were converted to analyze format using medcon. The SPM2 program was used to realign and normalize the PET images. Regions of interest were created from an MRI anatomical template. Values for the 12 anatomical regions were calculated for all scans. These values were then scaled to compensate for the total activity measured. Analysis of the RIO for each subject showed no difference between the pretreatment, 1 week or 6-8 weeks post therapy scans. FDG distribution was uniform amongst all regions and similar to 2 healthy control subjects.
Conclusions: Severe OSA does not appear to alter cerebral FDG distribution, which was also not affected by CPAP treatment.
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