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J Nucl Med. 2008; 49 (Supplement 1):228P
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Neurosciences: Neurology

Neurology Posters

Investigation of usability of FDG PET in comparing acute with chronic methyl mercury poisoning (Minamata disease)

Seigo Fujita1, Kazuhito Tsuruta2, Shigeki Nagamachi3, Kiyohisa Kamimura1, Yoshiro Umemura1, Ryuichi Nishii3, Hideyuki Wakamatsu3, Shozo Tamura3 and Toshiro Fujimoto1

1 Radiology, Fujimoto Hayasuzu Hospital, Miyazaki, Japan; 2 Internal Medicine, Koga General Hospital, Miyazaki, Japan; 3 Radiology, Miyazaki Medical College, Miyazaki, Japan

980

Objectives: Minamata disease (MD), which was caused by ingestion of methylmercury-contaminated seafood from Minamata bay in Japan, was difficult to diagnosis with only CT, MRI. In addition, clinical symptom was different in acute MD and chronic MD, so diagnosis was very difficult. Previously we reported the FDG PET findings in MD, but this purpose was to investigate of usability of FDG PET in comparing acute with chronic MD; no previous study assessed FDG PET in comparing acute with chronic MD.

Methods: Eight patients (aged 46-75 years) that had been verified and certified neurologically and epidemiologically as having MD were investigated with FDG PET and MRI, and underwent a neurological examination by one of us. PET images were obtained 1 hour after injection of 185 MBq of FDG. We classified in two groups (acute MD, chronic MD) by the onset time and compared between two groups about each brain glycometabolism by Statistical Parametric Mapping analysis.

Results: FDG PET finding of Acute MD group showed low accumulation in primary motion perception fields, intra-cerebella area (iCA) and olfactory sensation area (OSA), but MRI images showed no atrophy. FDG PET finding of chronic MD group showed low accumulation in only parts of parietal-temporal lobe including primary motion perception fields, and showed no definite low accumulation in iCA and OSA.

Conclusions: Even in patients of acute MD without cerebella atrophy, glycometabolism was significantly decreased or loss in iCA and OSA compared with chronic MD. Particularly there is not reported to low mglycoetabolism of OSA in MD, and there is possibility of a cause to the acute MD onset.





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Right arrow Articles by Fujimoto, T.