SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):226P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Dubroff, J.
Right arrow Articles by Newberg, A.
PubMed
Right arrow Articles by Dubroff, J.
Right arrow Articles by Newberg, A.

Neurosciences: Neurology

Neurology Posters

Effect of chemotherapy on FDG-PET brain activation patterns

Jacob Dubroff1, Miguel Hernandez-Pampaloni1, Nancy Wintering1, Joshua Scheuermann1 and Andrew Newberg1

1 Nuclear Medicine Section, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania


Formula

972

Objectives: To assess whether chemotherapy affects blood glucose brain activation patterns in cancer patients.

Methods: Changes in FDG-PET brain activation patterns of 20 patients, 17 male and 3 female, with a previous histological diagnosis of squamous cell carcinoma and no neurological history were retrospectively analyzed. Two groups of patients (n=10 each) were identified who had serial FDG-PET scans: one in which patients were treated with radiation and/or surgery (mean age 58 yrs +/-15) and one in which patients received adjunct chemotherapy in addition to the aforementioned therapies (mean age 58 yrs +/-13). Using a previously validated method, ROI’s were identified of 80 discrete neuroanatomical locations in each of the 40 scans identified. Each ROI was then compared to a relative ROI of brain activation. The calculated relative brain activity for each neuroanatomical location was then subtracted between time-points for each patient. A t-test was used to compare changes in brain activity between the two experimental groups.

Results: We found significant changes (p < 0.05) in 19 of the 80 neuroanatomical locations examined. Decreases in FDG uptake in chemotherapy relative to non-chemotherapy patients were found in 5 locations (see table). Increases in glucose metabolism were found in 14 locations including the left angular gyrus, right hippocampus as well as bilaterally in the parahippocampal formations.

Conclusions: Chemotherapy affects brain glucose metabolism which implies a molecular basis for changes observed in cognition, learning and memory.


Figure 1
% Change in Brain Activation from Initial PET Scan





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Dubroff, J.
Right arrow Articles by Newberg, A.
PubMed
Right arrow Articles by Dubroff, J.
Right arrow Articles by Newberg, A.