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Neurosciences: NeurologyNeurology Posters |
1 Radiology, The Catholic University of Korea, Seoul, South Korea
971
Objectives: CAA is known as an important cause of spontaneous cortical-subcortical intracranial hemorrhage in normotensive elderly. However, the patients with CAA can also manifest leukoencephalopathy, brain atrophy, and ischemia. Hypoperfusion resulting from vessel wall deposition of beta-amyloid may be responsible for these manifestations. We would like to verify the pathologic effect of CAA on cerebral hypoperfusion and ischemia by using Tc-99m-ECD brain perfusion SPECT.
Methods: Total eleven patients (M: 5, F: 6, Age range: 48-75 years (65.0±13.3)) with clinically and radiologically proven probable CAA (more than 15 petechial hemorrhagic or hemosiderin deposition foci on the brain MRI) and have undergone Tc-99m-ECD SPECT together are included in our study as a patient group. Tc-99m-ECD SPECT scans were also obtained in 13 age-matched healthy control subjects (M: 7, F: 6, Age range: 60-79 years (66.7±6.4)) for comparison. Relative rCBF in patients and normal controls were compared using SPM2.
Results: In comparison with normal controls, the hypoperfusion areas are as follows: inferior parietal lobule of both parietal lobes, (BA 40), middle temporal gyrus of left temporal lobe (BA 39), postcentral gyrus of right parietal lobe, superior temporal gyrus of right temporal lobe (BA 22), superior temporal gyrus of right fontal lobe (BA 10), inferior temporal gyrus of left temporal lobe (BA 20), both caudate bodies.
Conclusions: Cerebral perfusion was significantly decreased in patients with diffuse petechial CAA. These findings are very informative to predict the risk of the cerebral hypoperfusion in patients with CAA resulting in leukoencephalopathy, atrophy, and ischemia.
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