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J Nucl Med. 2008; 49 (Supplement 1):225P
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Neurosciences: Neurology

Neurology Posters

Assessment of the hemodynamic changes after encephaloduroarteriosynangiosis combined with bifrontal encephalogaleosynangiosis in pediatric patients with Moyamoya disease

Yu Kyeong Kim1, Yoo Sung Song1, Ho Young Lee1, Seung Ki Kim1, Byung-Kyu Cho1, Keun Wook Kang1, June Key Chung1, Myung Chul Lee1 and Dong Soo Lee1

1 Seoul National University College of Medicine, Seoul, South Korea


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968

Objectives: Encephaloduroarteriosynangiosis (EDAS) surgery combined with bifrontal encephalogaleosynangiosis (EGS) in pediatric moyamoya disease has been proposed with an aim of improving blood supply to the anterior frontal area which is a crucial in intellectual development. In this study, we evaluated cerebral hemodynamic changes after EDS combined with EDAD using brain perfusion SPECT.

Methods: Total 36 pediatric patients (M:F=13:23, age; 9.8±3.4 yrs) who performed EDAS with EGS (n=19) or EDAS only (n=17) for moyamoya disease were enrolled. Pre- and postoperative basal/acetazolamide challenged cerebral blood flow (CBF) conferring with cerebellar uptake and cerebral vascular index (CVRI) were calculated in the vascular territories for anterior cerebral artery (ACA) and middle cerebral artery (MCA) which was determined using standard ROIs based on Korean template.

Results: Overall basal/acetazolamide stress CBF and CVRI for each brain regions after surgery were improved. However, t-test revealed only some indexes to be significant. In children having EDAS with bifrontal EGS, basal and aetazolamide perfusion and CVRI were significantly improved in the contralateral ACA territories as well as ipsilateral ACA and MCA territory in patients receiving EDAS with bifrontal EGS. However, the children had a perfusion improvement in only ipsilateral vascular territory but not in contralateral ACA territory.

Conclusions: Quantitative perfusion SPECT demonstrated that EDAS combined with EGS surgery led the significant hemodynamic improvement in bifronal ACA territory, which was not expected in EDAS only surgery.





This Article
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Right arrow Email this article to a friend
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Right arrow Articles by Lee, D. S.
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Right arrow Articles by Kim, Y. K.
Right arrow Articles by Lee, D. S.