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J Nucl Med. 2008; 49 (Supplement 1):224P
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Neurosciences: Neurology

Neurology Posters

Evaluation of impaired cerebral blood flow in type-2 diabetics with TC-99m HMPAO brain SPECT

Sadaf Butt1, Shabana Saeed2 and Javaid Irfan1

1 NORI, Islamabad, Pakistan; 2 PIEAS, Islamabad, Pakistan

967

Objectives: To evaluate of the effect of duration and control of diabetes on cerebral blood flow in type-2 diabetics.

Methods: Cerebral perfusion was semiquantitatively assessed in 40 type 2 diabetics. Normal data base was created by scans of 20 normal subjects. 18 subjects had disease duration less than 10yrs, while 22 subjects were diabetic for more than 10 yrs. Control of diabetes was assessed through HbA1c test. HbA1c level of 8% and below was the selected cutoff value for controlled disease. ROI’S of diabetic patients were compared with those of control group and were classified as hypoperfused, hyperperfused or normal.

Results: rCBF in type 2 diabetics were found considerably different from normal control values with high degree of significance. Diabetics with duration more than 10 years were found to have more hypo and hyperperfused areas as compared to diabetics with duration less than 10 years (p<0.001) while there was no difference in number of hypo and hyperperfused ROI’s between controlled diabetics and uncontrolled diabetics (p>0.05). Hyperperfused ROI’s in diabetics for less than 10 years was not found significantly different from that found in normal controls (p>0.05). While diabetics for more than 10years showed significantly more number of hyperperfused ROI’s as compared to normal subjects (p<0.001). All the regions of cerebral cortex were found to have perfusion abnormalities, frontal cortex showed greatest percentage of hyperperfused ROI’s and occipital cortex had greatest percentage of hypoperfused ROI’s.

Conclusions: The study confirmed that type 2 diabetics start developing perfusion changes very early. It was also seen that these alterations in cerebral blood flow progress with duration of the diabetes, however no effect of control of blood sugar on perfusion abnormalities could be established.





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Right arrow Articles by Irfan, J.