| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
|
|
|||||||||
|
|
Neurosciences: NeurologyNeurology Posters |
1 Radiology & Neurology; 2 Radiology; 3 Psychiatry, University of Michigan, Ann Arbor, Michigan; 4 Radiology, University of Washington, Seattle, Washington
950
Objectives: To investigate cognitive correlates of posterior cingulate hypometabolism in Parkinson disease (PD) and to determine regional cerebral specificity of such cognitive marker(s).
Methods: Twenty-three PD patients without dementia (Hoehn and Yahr stages I-III, age 61.8+9.7; 43-79, MMSE 28.0±1.4) underwent FDG PET imaging and neuropsychological assessment. A battery of tests of visuospatial function and visual memory were used for analysis. Volume-of-interest and 3D-SSP image analysis was performed. PET data were normalized to the pons.
Results: Stepwise multiple regression analysis using the selected cognitive variables and regional posterior cingulate cortical metabolism identified significant regression only for the WMS Visual Reproduction Delayed Recall parameter (VI-PROC, P<0.001). Voxel-based linear regression analysis of the FDG PET (ordinate) and VI-PROC (abscissa) data demonstrated a significant and widespread bilateral (right more than left) hemispheric pattern most prominently involving the posterior cingulum, precuneus and orbitofrontal regions.
Conclusions: Posterior cingulate hypometabolism has been recognized as an early imaging biomarker of Alzheimer and parkinsonian dementias. The present results indicate that a visual memory recall test had robust metabolic correlations with posterior cingulate, precuneus and orbitofrontal regions that are known to become involved in PD dementia. A visual memory recall test can be used as a simple clinical screening test to select at risk patients for further evaluation with FDG PET.
Research Support: DOE
| ||||||||||||||||||||||||||||||||||||||
