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J Nucl Med. 2008; 49 (Supplement 1):217P
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Neurosciences: Neurology

Neurology Posters

Association between CSF biomarkers and FDG uptake in probable Alzheimer’s disease

Ralph Buchert1, Sönke Arlt2, Florian Wilke1, Fabian Wenzel3, Frank Thiele4, Stewart Young3 and Holger Jahn2

1 Nuclear Medicine; 2 Psychiatry, University Medical Center Hamburg, Hamburg, Germany; 3 Digital Imaging, Philips Research, Hamburg, Germany; 4 Molecular Imaging, Philips Research, Aachen, Germany

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Objectives: Biomarkers that are useful in the diagnosis of Alzheimer’s disease (AD) include CSF markers and brain FDG PET. However, their relation is not well understood.

Methods: The correlation between FDG uptake and CSF Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau181) was investigated in 34 subjects with probable AD. SPM2 was used for this purpose.

Results: Proportionally scaled FDG uptake was reduced in the AD subjects compared to 19 controls bilaterally in precuneus / posterior cingulate, temporo-parietal cortex, and mid frontal cortex (FDR=0.05). Single AD subject analysis at p=0.001 (uncorr) revealed a total volume of significant hypometabolism ranging from 5.3 to 259.4 ml. This hypometabolic volume showed a highly significant negative correlation with MMSE (r=-0.587, p=0.000), but it was not correlated with Aβ1-42 (p=0.540), t-tau (p=0.102), or p-tau181 (p=0.248). Voxel-based correlation analyses at FDR=0.05 showed that the increased local variance of scaled FDG uptake in the AD subjects could be accounted for by a positive correlation with MMSE to a large extent. There was no correlation with any of the CSF markers at this significance level. Explorative correlation analyses (p=0.05 uncorr) revealed a negative correlation of scaled FDG uptake and Aβ1-42 in precuneus / posterior cingulate, temporo-parietal cortex, and mid frontal cortex, predominantly in the left hemisphere. t-tau and p-tau correlated positively with FDG uptake in temporo-parietal cortex, negatively in precuneus.

Conclusions: Although FDG uptake in probable AD was more strongly coupled to cognitive impairment, correlations were also observed with CSF biomarkers.





This Article
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Right arrow Articles by Jahn, H.