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J Nucl Med. 2008; 49 (Supplement 1):216P
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Neurosciences: Neurology

Neurology Posters

Simplified voxel based and automatic VOI analysis of C-11 PIB images using subject specific PET templates

Sun-Young Chae1, Jae-Hong Lee2, Seung-Jun Oh1, Yeong-Hee Lee1, Ki-Chun Lim1, IL-Ki Hong1, Jin-Sook Ryu1, Dae-Hyuk Moon1, Duk L. Na3 and Jae-Seung Kim1

1 Nuclear Medicine; 2 Neurology, Asan Medical Center, U of Ulsan Coll of Medicine, Seoul, South Korea; 3 Neurology, Sungkyunkwan U School of Medicine, Seoul, South Korea

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Objectives: We developed simplified method for the voxel based and automatic VOI analysis of C-11 PIB PET images using subject specific PIB PET templates and compared the outcome of this method with ligand specific PET and standrd MR template based methods.

Methods: Seven patients (mean age:73 yrs, M/F=3/4) with Alzheimer’s disease (AD) and 6 normal controls (mean age:68 yrs, M/F=1:5) underwent 90 min dynamic PET scan after injection of 10 mCi C-11 PIB and T-1 weighted MRI. Region to cerebellum ratio parametric image (ratio image) was obtained from 60-90 min sum image. AD and normal SS PIB PET templates were created by the spatial normalization of MR coregistered ratio images of AD and control groups to T1 MR MNI template using SPM2. We assessed the outcome difference of voxel based and automatic VOI analysis using three parametric images: MR template based spatially normalized ratio (MR-ratio) image; ligand specific (nomral) PET template based spatially normalized ratio (LS PET-ratio) image; and subjects (normal and AD) specific PET templates based spatially normalized ratio (SS PET-ratio) image.

Results: All of voxel based analyses using three parametric images revealed increased PIB retention in specific brain regions such as bilateral orbitofrontal and temporoparietal cortices and posterior cingulated gyri of AD. Correlation of PIB retention values in SS PET-ratio and MR-ratio images was higer (r=0.98, p<0.001) than that in LS PET-ratio and MR-ratio images (r=0.92, p<0.001).

Conclusions: Voxel based and automatic VOI analysis of C-11 PET images can be simply and accurately performed using subject specific PIB PET templates without MRI.





This Article
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Right arrow Articles by Kim, J.-S.
PubMed
Right arrow Articles by Chae, S.-Y.
Right arrow Articles by Kim, J.-S.