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J Nucl Med. 2008; 49 (Supplement 1):211P
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Neurosciences: Basic Science

Basic Science Posters

PET measurement of regional rates of cerebral protein synthesis (rCPS) with L-[1-11C]leucine in healthy males under propofol sedation

Shrinivas Bishu1, Kathleen Schmidt1, Michael Channing3, Mei Qin1, Aaron Unterman1, Alan Zametkin2, Peter Herscovitch3, Zenaide Quezado4, William Kammerer4 and Carolyn Smith1

1 Laboratory of Cerebral Metabolism, NIMH; 2 Mood/Anxiety Disorder Program, NIMH; 3 PET Dept, CC; 4 Dept of Anesthesiology, CC, National Institutes of Health, Bethesda, Maryland

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Objectives: The quantitative L-[1-11C]leucine PET method makes it possible to determine if rCPS changes with physiologic interventions and disease states. We studied the effect of deep propofol sedation on rCPS.

Methods: Seven males (20-24y) were studied awake and during sedation. They were dynamically scanned for 90 min following tracer injection. ROI-based analyses were used to estimate kinetic model rate constants from which the fraction of the precursor pool for protein synthesis derived from arterial plasma ({lambda}) was calculated. rCPS were calculated from the rate constants, {lambda}, and plasma leucine concentrations. Propofol was titrated to keep subjects motionless.

Results: {lambda} was ~4% higher during sedation. rCPS tended to be slightly lower, but effects were not statistically significant.

Conclusions: These preliminary results suggest deep sedation with propofol has little or no effect on rCPS. This information will facilitate using L-[1-11C]leucine to study patient groups who require sedation during scanning.

Research Support: IRP, NIMH; CC,NIH; Fragile X Research Foundation


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