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J Nucl Med. 2008; 49 (Supplement 1):209P
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Neurosciences: Basic Science

Basic Science Posters

The effects of long-term addiction of cocaine on rat dopaminergic/serotonergic systems

Tong-Hsien Chow1, Wei-Chan Lin1, Chi-Wei Chang1, Shyh-Jen Wang2, Ren-Shyan Liu2 and Jeng-Jong Hwang1

1 Department of Biomedical Imaging & Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 2 Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan


Formula

902

Objectives: The purpose of this study is to investigate the influence of dopamine and serotonin neurons of rat brain by long-term (three doses per week for four months) addiction of cocaine via simulating human chronic psychostimulant abusers.

Methods: We applied the neuronal imaging of [11C]raclopride-microPET and [123I]ADAM-SPECT for specific binding assays (striatum/midbrain) in D2 receptor and serotonin transporter after cocaine treatment, respectively. In addition, animal behavioral testing, magnetic resonance imaging (MRI) and immunohistochemistry (IHC) were also applied to assess the functional and anatomical changes of neuronal systems during and after the drug treatment.

Results: Animal behavioral assay showed that the maximum activity of locomotion was observed in the first month and gradually recovered to the baseline at the 11th week after thirty-three doses of cocaine injections. MicroPET brain images significantly revealed the decrease uptake of [11C]raclopride at D2 receptor. [123I]ADAM-SPECT images also showed the similar result up to the 11th week of treatment followed by a recovery during the 11th to 17th week. Though animal MRI indicated that no symptoms of hemorrhage or edema were found even two months after cessation of cocaine treatment, however, immunohistochemical examination revealed serious neuronal damage with decrease in TH-like IHC positive expression and increase glial cell level throughout the brain areas indicated the cocaine addiction.

Conclusions: We concluded that dopaminergic system still plays a central mediator for chronic cocaine response.

Research Support: Yen Tjing Ling Medical Fundation grant





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