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J Nucl Med. 2008; 49 (Supplement 1):208P
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Neurosciences: Basic Science

Basic Science Posters

Comparison of [11C]raclopride kinetics in awake and anesthetized rats using the RatCAP Awake Rat Brain PET System

David Schlyer1, Paul Vaska1, Craig Woody2, Daniela Schulz1, Sachin Junnarkar3, Sudeepti Southekal4, Sri-Harsha Maramraju4, Wynne Schiffer1 and David Alexoff1

1 Medical; 2 Physics, BNL, Upton, New York; 3 Biomedical Engineering, USB, Stony Brook, New York; 4 Instrumentation, BNL, Upton, New York

898

Objectives: Our Rat Conscious Animal PET (RatCAP) system has been developed specifically to allow brain imaging in the awake, freely moving rat. Miniaturization of the scanner and direct attachment to the rat’s head allows a direct comparison of the brain function using any PET tracer while the rat is awake or anesthetized.

Methods: The original prototype RatCAP PET scanner for conscious rat brain imaging has undergone a major redesign which provides a factor of 2 increase in coincidence sensitivity at the cost of only ~10% increase in size and weight. In these experiments, rats were surgically implanted or purchased with venous cannula to allow direct injection of the radiotracer. The rats were placed in the RatCAP, injected with radiotracer and scanned. Scans were carried out for approximately one hour. The list mode data was reconstructed using a full system matrix calculated for this scanner. Kinetics were analyzed and uptake values calculated using a Logan plot.

Results: Previous results from BNL (Schiffer et al) showed there was a significant difference between the uptake in the awake and the anesthetized rat. A further direct comparison of the kinetics and biodistribution will be made between a larger sample of rats under ketamine anesthesia and those who are awake during the PET scan using the RatCAP.

Conclusions: The RatCAP awake animal scanner allows imaging of brain activity and receptor availability in the awake animal. The effects anesthesia on the kinetics and biodistribution of PET radiotracers can be significant.

Research Support: Supported by U.S. Department of Energy (OBER) under Contract No. DE-AC02-98CH10886.





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