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Cardiac function and ventricular dyssynchony in ischemic heart disease: Comparison of planar and GSPECT RNA

¹ Nuclear Medicine, Cochin Hospital, Paris, France

890

Objectives: Intra and inter ventricular (V) left ventricular (LV) and right ventricular (RV) dyssynchrony (D) are used as the basis for biV pacing in the treatment of heart failure. Planar RNA using Fourier Phase Analysis (FPA) is used for the characterization of intraV and interV LV and RV D. The utility of GSPECT RNA in this indication is not well defined. We aimed to compare the use of both planar and GSPECT RNA for the quantification of D.

Methods: Were included 40 consecutive patients with ischemic heart disease addressed for LV function evaluation with planar and GSPECT RNA. Planar RNA was processed for FPA with XT-RNA commercial software. GSPECT RNA was processed with the 35% maximal activity threshold method. For both planar and GSPECT RNA, global LV and RV FPA were calculated in degrees: LV-SD reflects intraV global LV D. InterV D was calculated as the difference between mean LV and mean RV FPA. For planar RNA, the difference between antero-lateral (AL) and antero-septal (AS) FPA of the LV were calculated: AL-AS D (intraV D). For GSPECT RNA, this corresponded to the difference between segment 13 and 16 (16 segment LV model).

Results: For planar RNA, LVEF was correlated to LV-SD (r=-0.82, P <0.0001) with a trend to interV D (rho=-0.32, P=0.05) and intraV D (rho=-0.28, P=0.094). For GSPECT RNA, LVEF was correlated to LV-SD (rho=-0.70, P<0.0001) and intraV D (r=-0.4, P =0.013) and a trend for interV D (rho=-0.318, P=0.053). On stepwise regression analysis, the only correlated factor was LV-SD (r=0.75, P <0.0001) with planar RNA while with GSPECT RNA, these were both LV-SD and intraV D (r=0.72, P<0.0001).

Conclusions: With both planar and GSPECT RNA, LVEF was highly correlated to global LV D but not to interV D. The influence of LV intraV dyssynchronism seems also important when determined with GSPECT RNA but not planar RNA.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Daou, D. Articles by Tawileh, M. PubMed Articles by Daou, D. Articles by Tawileh, M.