J Nucl Med. 2008; 49 (Supplement 1):205P
Cardiovascular: Clinical ScienceClinical Science Posters |
Value of right ventricular output (RVO) and RVEF using gated blood pool (gbp)-SPECT in patients with pulmonary arterial hypertension (PAH): A comparative study with right cardiac catheterization (RCC)
Vincent Dunet1,
Emmanuel Bergot1,
Maxime Le Gall1,
Alexis Hugentobler1,
Gilles Grollier1,
Eric Saloux1,
Gérard Bouvard1,
Gérard Zalcman1 and
Denis Agostini1
1 CHU Cote de Nacre, Caen, France
889
Objectives: This study examined the feasibility of gbp-SPECT to assess RSV, RVO and RVEF in pts with PAH in comparison with right cardiac catheterization.
Methods: 31 pts (14M-8F:67+/-10 yrs) with proven PAH by thermodilution during RCC and 9 normal subjects (NS) without cardio-vascular history (5M-4F:48+/-16 yrs) were included into the study.After injection of 1100 MBq of 99mTc-pertechenate, following in vivo labeling protocol, all pts underwent a gbp-SPECT using a dual-head camera with LEHR collimator, 64x64 matrix, 16 frames/cycle over a 105° in 16 steps. RVO was calculated by RSVxHR. RSV and RVEF were calculated from reconstructed gbp-SPECT with QBS software.
Results: 9 pts with PAH and one without PAH were excluded because of arrhythmia or failure of QBS reconstruction. Although age is significantly different between PAH and NS (p=0.0004); RVO and HR were not significantly different. However, RVEF was significantly lower in PAH than in NS (p=0.01). RVO and HR were not significantly different during RCC and gbp-SPECT.However, RSV was lower within RCC in PAH (p=0.03).RVEF was never measured by RCC.
Conclusions: Assessment of RVO and RVEF was feasible and reliable using gbp-SPECT in pts with PAH, which could be an appropriate non invasive technique for the diagnosis and follow-up of PAH. However, further studies are needed to address the impact of gbp-SPECT in a large sample of pts with PAH.
