SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):204P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Higuchi, T.
Right arrow Articles by Bengel, F.
PubMed
Right arrow Articles by Higuchi, T.
Right arrow Articles by Bengel, F.

Cardiovascular: Clinical Science

Clinical Science Posters

Rb-82/F-18 FDG PET-CT to characterize cardiac involvement in advanced sarcoidosis

Takahiro Higuchi1, David Moller2, Jennifer Merrill1 and Frank Bengel1

1 Nuclear Cardiology; 2 Medicine, Johns Hopkins University, Baltimore, Maryland

885

Objectives: In sarcoidosis as an inflammatory disease, myocardial involvement and its activity are recognized as essential for prognosis. Literature on the usefulness of F-18 FDG PET for detection of cardiac sarcoidosis is scarce, especially in patients with advanced stages of the systemic disease.

Methods: Myocardial resting perfusion and cardiac and whole-body glucose utilization were studied by Rb-82 and FDG PET-CT under fasting conditions (>6h) in 11 pts with longstanding history of sarcoidosis (6±4yrs), and increased clinical risk of cardiac involvement according to Japanese Ministry of Health criteria (n=9). None had history of DM and ischemic heart disease. LVEF was low at 37±12%, ECG abnormalities were reported in 10/11 pts, and 6/11 had ICD implants.

Results: Focal extra-cardiac FDG uptake, indicating systemically active sarcoidosis, was observed in 7/11 pts. Focal cardiac FDG uptake consistent with myocardial involvement was found in 3 pts which all had active extra-cardiac involvement. Regional myocardial perfusion defects without focal FDG uptake, probably reflecting inactive post-inflammatory fibrosis, were found in 3 additional pts – all without extra-cardiac active lesions. 2 pts exhibited diffuse cardiac FDG uptake, which is nonspecific and may be a consequence of heart failure. Imaging patterns were not related to clinical parameters such as EF, duration of disease, ECG abnormalities and steroid treatment.

Conclusions: Even advanced stages of sarcoidosis, different patterns of myocardial perfusion and metabolism are identified by PET-CT. Integration with extracardiac inflammatory foci may be helpful for interpretation of active cardiac involvement. The prognostic value of these individual patterns will need to be defined in further follow up studies.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Higuchi, T.
Right arrow Articles by Bengel, F.
PubMed
Right arrow Articles by Higuchi, T.
Right arrow Articles by Bengel, F.