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Cardiovascular: Clinical ScienceClinical Science Posters |
1 Medicine [Cardiology], Emory:Crawford Long Hospital, Atlanta, Georgia
881
Objectives: Use of CT for attenuation correction in PET Rb-82 MPI has raised controversy about the validity of the method. We compared MPI performed in the same patient [pt] by both Positron HZL [sPET] and Siemens Biograph-64 [PET/CT].
Methods: Pts were referred for PET for clinical indications, and we identified pts who had PET/CT and sPET within 3 years [n=112]. Knowing the date--but not results of PET#2 [usually PET/CT]--we reviewed reports of cardiac caths, hospital and clinic visits, and test results to predict the clinical likelihood that PET#2 would be the same as or different from PET #1, or uncertain, due to inconclusive clinical information. We blindly classified reports of both PETs, as same, different or equivocal. sPET used a Ge-68 rod source for attenuation correction, and a normal file [n=50 pts] which predicted coronary arteriographic results. PET/CT used 2.7-sec-CT scans during free breathing--3 at rest and 3 after stress MPI [4 mSv]. Using the CT showing best registration with MPI, we compared pts to a normal file [n=17]. 2,200 PET/CT scans showed good registration of 1 or more of the 3 CTs with the MPI images in >98% of patients, rarely requiring a realignment tool.
Results: Clinical information predicted results of PET#2 to be the same [n=63], different [n=13], or uncertain [n=36]. When clinical data predicted them to be the same, PET#2 agreed with PET#1 in 59/63 [94%, 95%CI= 85-97%]. When clinical prediction was uncertain, only 19/36 [53%, 95%CI= 37-68%] agreed. When clinical data predicted change, 12/13 [92%, 95%CI= 66-98%] of PET#2 differed from PET#1.
Conclusions: PET/CT MPI results agree closely [94%] with standard PET MPI, using a rotating rod source, which supports validity of PET/CT.
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