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J Nucl Med. 2008; 49 (Supplement 1):200P
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Cardiovascular: Clinical Science

Clinical Science Posters

Comparison of cardiac magnetic resonance with gated SPECT for evaluation of left ventricular function and volumes in patients with multiple perfusion defects

Ahmed Fathala1, Ahnaf Arafa1, Abdelaziz Alsugair1 and Mohei Abouzied1

1 Radiology, King Faisal Hospital, Riyadh, KSA, Riyadh, Saudi Arabia

866

Objectives: Gated SPECT is an accurate technique for assessment of myocardial perfusion (MP), Left Ventricular Ejection Fraction (LVEF), End-diastolic Volume (EDV) and End-systolic Volume (ESV). Recent studies have suggested that there are large variation and discrepancies in assessment of LVEF and volumes by gated SPECT. We sought to investigate the correlation between LVEF and volumes calculated by gated SPECT and Cardiac Magnetic Resonance (CMR) in patients with multiple fixed perfusion defects.

Methods: Twenty two patients with multiple fixed perfusion defects were referred to undergo CMR. The average time between CMR and SPECT was approximately 4 weeks. EF, EDV, and ESV derived automatically form gated SPECT using commercially available software (QGS). In the CMR studies, the endocardial and epicardial borders were delineated manually in the short axis planes to calculate the LVEF and volumes.

Results: 22 patients were studied (14 males, 8 females, mean age of 62 years ± 3). There is a significant correlation between the LVEF measured by gated SPECT and CMR (43 ± 3.9 %, vs. 41 ± 3.3%, r = 0.51, p = 0.01). Furthermore; The EDV and ESV measured by both modalities showed significant correlation as well (EDV 122 ± 9.0 ml vs. 144 ± 10.0 ml, r = 0.76, p= 0.001) and (ESV 69.0 ± 8.0 ml vs. 86.0± 9 ml, r = 0.51, p = 0.023).

Conclusions: The LVEF, EDV, and ESV obtained by gated SPECT are accurate, reproducible and have important prognostic implication in patients with ischemic cardiomyopathy.





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Right arrow Articles by Abouzied, M.