SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):19P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Lubberink, M.
Right arrow Articles by Lammertsma, A.
PubMed
Right arrow Articles by Lubberink, M.
Right arrow Articles by Lammertsma, A.

Oncology-Clinical Diagnosis: Solid Tumors

Breast Cancer

Validity of 3'-[18F]fluoro-3'-deoxythymidine standardized uptake value for chemotherapy response evaluation in breast cancer

Mark Lubberink1, Jasper Emmering1, Carla Molthoff1, Jacobus van der Hoeven2, Albert Windhorst1, Otto Hoekstra1 and Adriaan Lammertsma1

1 Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, Netherlands; 2 Internal Medicine, Alkmaar Medical Centre, Alkmaar, Netherlands

73

Objectives: The aim of the present study was to compare the relationship between standardized uptake value (SUV) and net influx rate of 3'-[18F]fluoro-3'-deoxythymidine (FLT), as determined by tracer kinetic modeling, before and after chemotherapy of breast cancer.

Methods: Stage III (locally advanced) and stage IV breast cancer patients (N=30) underwent 60 min 2D dynamic FLT PET scans on an ECAT Exact HR+ scanner shortly before and 3 weeks after onset of chemotherapy. Volumes of interest were defined at a 70% threshold over the primary tumor or largest lesion in a summed image. Data were analyzed by non-linear regression using an irreversible two-tissue compartment model, including blood volume component together with a metabolite-corrected image-derived input function, yielding the net FLT influx rate Ki. SUV values, normalized for weight (SUVW), lean body mass and body surface area, were calculated for the 50-60 min interval.

Results: The slope of the linear regression between SUVW and Ki increased from 72.9 (standard error SE 9.0) at baseline to 91.0 (SE 4.5) post chemotherapy, with similar changes for the other SUV measures. Correlation between SUVW and Ki improved post chemotherapy (r2 0.94) compared to baseline (r2 0.71).

Conclusions: A significant difference in the relationship between SUV and Ki at baseline and post chemotherapy was found. Unchanged net FLT influx rate post chemotherapy corresponded to a 25% increase in SUV compared with baseline values. SUV has to be used with caution when evaluating breast cancer chemotherapy response using FLT.

Research Support: Grant #IMG0402756 of The Susan G Komen Breast Cancer Foundation





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Lubberink, M.
Right arrow Articles by Lammertsma, A.
PubMed
Right arrow Articles by Lubberink, M.
Right arrow Articles by Lammertsma, A.