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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Gohar, S. Articles by Gayed, I. PubMed Articles by Gohar, S. Articles by Gayed, I.

Myocardial perfusion abnormalities & the subsequent clinical implications in patients with esophageal & lung cancer after chemoradiation therapy

¹ Nuc Medicine; ² Rad Onc; ³ Rad Physics; ⁴ Cardiology, MD Anderson Cancer Center, Houston, Texas

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Objectives: To investigate the clinical implications of radiation therapy (RT) related myocardial perfusion Imaging (MPI) abnormalities in patients with esophageal cancer (EC)& Lung Cancer (LC).

Methods: We retrospectively compared the results of 15 patients with EC & 22 patients with LC who had MPI before and after chemoradiation therapy(CRT).New MPI defects in the RT field were considered related to RT.Followup was done to evaluate for cardiac complications.

Results: 15 patients with EC & 22 with LC were included.The mean radiation dose to the heart was 29.6 Gy in EC & 17.6 Gy in LC,the mean heart volume involved was 746.6cc & 654.2cc in EC and LC respectively.All EC patients had normal pre-RT MPI results except 2.Repeat MPI studies were performed at a mean interval of 7.2 mo from end of RT.6 patients showed abnormal MPI of whom 2 remained asymptomatic,2 developed Afib after surgery but remained alive,1 developed chest pain but remained alive and 1 developed bradycardia,AV block & expired from heart failure.In the LC group,all except 1 had normal pre-RT MPI results.Repeat MPI studies were performed at a mean interval of 7.3 mo from end of RT.Of the 22 patients,7 showed abnormal MPI,of whom 3 remained asymptomatic & alive,2 developed AF & died due to stroke & mets to the brain,1 developed chest pain but remained alive and 1 developed pericardial effusion,non obstructive CAD & expired from CHF.In all 66% of EC & 57% LC patients developed clinical abnormalities.

Conclusions: RT induced MP defects are associated with cardiac morbidity & mortality observed more frequently in esophageal cancer patients than in lung cancer.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Gohar, S. Articles by Gayed, I. PubMed Articles by Gohar, S. Articles by Gayed, I.