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Cardiovascular: Clinical ScienceClinical Science Posters |
1 Medical U of SC, Charleston, South Carolina
853
Objectives: Statistically insignificant differences between 99m-TC TF and MIBI diagnostic sensitivity (SEN) have been reported using older scanner technology, though improved efficiency was demonstrated using TF. We sought to determine if current generation gamma cameras might reveal greater differences in the diagnostic accuracy using coronary angiography (CA), with 
50% occlusion indicative of obstructive lesions.
Methods: 207 consecutive patients received gated, dual, digital detector, attenuation corrected (AC) SPECT myocardial perfusion (MP) scans within 3 months of CA. Image analysis was performed by consensus amongst a nuclear medicine physician, a cardiologist and a cardiology and nuclear medicine fellow. Static and cine displays of gated images with and without AC, summed difference scores, patient history, EKG, stress reports, and TID scores were used to interpret MP as normal, having ischemia, scar, or mixed ischemia and scar. Patients were divided into 2 groups: No Known coronary artery disease (NK-CAD) and Known CAD (K-CAD).
Results:
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Improved SEN was seen using TF, especially in the NK CAD group (p=.07). A trend existed for more FN MIBI studies and of less clinical importance, more FP TF studies. No difference in non-diagnostic scans was detected. Specificity and negative predictive values were not obtained due to lack of CA with negative MP scans.
Conclusions: Our findings support marginally significant greater SEN of TF compared to MIBI in patients with NK CAD using optimal imaging parameters.
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